Archive for Aralık, 2007
It has been 50 years since scientists first created DNA in a test tube, stitching ordinary chemical ingredients together to make life’s most extraordinary molecule. Until recently, however, even the most sophisticated laboratories could make only small snippets of DNA — an extra gene or two to be inserted into corn plants, for example, to [...]
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DNA’nın metilasyonu gen anlatımını kontrol eden hücresel bir epigenetik programdır. Kanserleşmenin erken evresinde metillenme paterninin değişiklik gösterdiğinin anlaşılması kanser araştırmalarında önemli bir aşama olmuştur. Kanserin erken teşhisi genomdaki metilsitozin dağılımı saptanarak yapılabilir mi? Bu metilsitozinleri saptamada eş zamanlı high-throughput analizler ile tüm genom taraması yapılabilmiştir. Dolayısıyla DNA mikroararyleri (Oligonükleotit microararyler, BAC arrayleri) tümör epigenetiğinde de [...]
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miRNAs upregulate translation?
miRNAs are one of the hottest fields of research right now in molecular biology — they’re thought to regulate development, cancer progression, and probably everything else, too, since bioinformatics analyses show that up to 20% of the genome (and maybe more) are targeted by miRNAs. As a one-sentence primer on their function, miRNAs are transcribed [...]
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Looking back through the history of a species’ genome, mutations do indeed appear to be attracted to certain genomic locations (and likewise repelled by others). But appearances can be deceiving, and selection is a great illusionist. Mutations that initially occur at random may end up seeming to be “directed” in highly nonrandom patterns since most [...]
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